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CAS No 51264-14-3 , N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide

  • Name: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
  • Synonyms: m-AMSA; Amsidyl;Amsidine; AMSA P-D; Amsine; mAMSA;N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide; Acridinylanisidide; 51264-14-3; meta-Amsacrine;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 230-240 deg C
  • Density: 1.398 g/cm3
  • Refractive index: 1.688
  • Safety Statements: Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by intravenous route: nausea or vomiting, thrombosis distant from injection site, and bone marrow changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • EINECS: 257-094-3
  • Molecular Weight: 393.45886
  • InchiKey: XCPGHVQEEXUHNC-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,
    25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,
    24H,1-2H3,(H,22,23)
  • Molecular Formula: C21H19N3O3S
  • Molecular Structure:CAS No:51264-14-3 N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
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51264-14-3 AMSACRINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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51264-14-3 Amsacrine

  • Amsacrine
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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51264-14-3 Amsacrine

  • Amsacrine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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51264-14-3 Amsacrine

  • Amsacrine, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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51264-14-3 Amsacrine

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51264-14-3 Amsacrine

  • Amsacrine4'-(9-Acridinylamino)methanesulfon-m-anisidide
  • Germany SYNCHEM Laborgemeinschaft OHG [Manufacturer]
  • Tel: +49 (0) 5662 40873-0
  • Fax: +49 (0) 5662 40873-20
  • Address: SYNCHEM Laborgemeinschaft OHG
    Dr. Jaeger & Dr. Drinkuth
    Am Kies 2
    D-34587 Felsberg / Altenburg, Germany ,Germany
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51264-14-3 Amsacrine, 99%

  • Amsacrine, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
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51264-14-3 Amsacrine

  • China Vesino Industrial Co., Ltd. [Manufacturers]
  • Tel: +86-(22)-8128-9555
  • Fax: +86-(22)-2746-6330
  • Address: No.4 Xinglanyuan Building, Changjiang Road, Tianjin 300193, Tianjin,TianjinChina
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51264-14-3 Amsacrine

  • China Zonk Drug R&D Limited [Manufacturers]
  • Tel: +86-(20)-85660382
  • Fax: +86-(20)-85668670
  • Address: 3rd, 4th, 5th floor, B Building, Shangshehenglu, Tangxia, Guangzhou, ,GuangdongChina
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51264-14-3 AMSACRINE

  • China Vesino Industrial Co., Ltd. [Manufacturer]
  • Tel: +86 22 81289555/ +86 22 27455635
  • Fax: +86 22 27466330
  • Address: No.4 Xinglanyuan Building, Changjiang Road, Tianjin, China ,China
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References of N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
Title: Amsacrine
CAS Registry Number: 51264-14-3
CAS Name: N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide
Synonyms: 4¢-(9-acridinylamino)methanesulfon-m-anisidide; m-AMSA
Manufacturers' Codes: CI-880; NSC-249992; SN-11841
Trademarks: Amekrin (Warner-Lambert); Amsidine (Parke-Davis); Amsidyl (Pfizer)
Molecular Formula: C21H19N3O3S
Molecular Weight: 393.46
Percent Composition: C 64.10%, H 4.87%, N 10.68%, O 12.20%, S 8.15%
Literature References: Cytostatic agent with antiviral and immunosuppressive properties. Prepn: B. F. Cain et al., J. Med. Chem. 18, 1110 (1975). Synthesis and biological properties of spin-labeled amsacrine: B. K. Sinha et al., ibid. 19, 994 (1976). Mechanism of action: W. R. Wilson, Chem. N. Z. 37, 148 (1973). Pharmacologic disposition: R. L. Cysyk et al., Drug Metab. Dispos. 5, 579 (1977). Antiviral activity: D. M. Byrd, Ann. N.Y. Acad. Sci. 284, 463 (1977). Immunosuppressive properties: B. C. Baguley et al., Eur. J. Cancer 10, 169 (1974). Exptl antitumor properties: B. F. Cain, G. J. Atwell, ibid. 539. Efficacy in adult acute leukemia: S. S. Legha et al., Ann. Intern. Med. 93, 17 (1980). Toxicologic studies: K. L. Pavkov et al., U.S. NTIS Report PB-298106 (1979) 284 pp, C.A. 92, 34335c (1980). Review of pharmacology and clinical efficacy: J. Hornedo, D. A. Van Echo, Pharmacotherapy 5, 78-90 (1985).
Properties: LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov).
Toxicity data: LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)
 
Derivative Type: Hydrochloride
Manufacturers' Codes: NSC-141549
Molecular Formula: C21H19N3O3S.HCl
Molecular Weight: 429.92
Percent Composition: C 58.67%, H 4.69%, N 9.77%, O 11.16%, S 7.46%, Cl 8.25%
Properties: Crystals, mp 197-199°. LD50 i.p. in mice: ~60 mg/kg (Byrd).
Melting point: mp 197-199°
Toxicity data: LD50 i.p. in mice: ~60 mg/kg (Byrd)
 
Derivative Type: Methanesulfonate
Manufacturers' Codes: NSC-156303
Molecular Formula: C21H19N3O3S.CH3SO3H
Molecular Weight: 489.56
Percent Composition: C 53.97%, H 4.74%, N 8.58%, O 19.61%, S 13.10%
Properties: Crystals, mp 292-293°. LD50 i.p. in mice: ~24 mg/kg (Byrd).
Melting point: mp 292-293°
Toxicity data: LD50 i.p. in mice: ~24 mg/kg (Byrd)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Topoisomerase II Inhibitor.