Home > Name List By other > (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15, 16-oc...

CAS No 53-33-8 , (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one

  • Name: (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Synonyms: (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Cassenne; Parametasona; Parametasone; Dillar; Paramezone; Cortiden; Flumethone; Metilar; Parametasone [DCIT];
  • CAS Registry Number:
  • Melting Point: 228-241 ºC
  • Density: 1.32 g/cm3
  • Refractive index: 1.589
  • EINECS: 200-169-2
  • Molecular Weight: 392.461063
  • InchiKey: MKPDWECBUAZOHP-AFYJWTTESA-N
  • InChI: InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,
    2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,
    24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
  • Molecular Formula: C22H29FO5
  • Molecular Structure:CAS No:53-33-8 (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,<br />17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,<br />16-octahydro-6H-cyclopenta[a]phenanthren-3-one

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53-33-8 Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-

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53-33-8 Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-

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References of (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Title: Paramethasone
CAS Registry Number: 53-33-8
CAS Name: (6a,11b,16a)-6-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 6a-fluoro-16a-methylprednisolone; 16a-methyl-6a-fluoroprednisolone
Molecular Formula: C22H29FO5
Molecular Weight: 392.46
Percent Composition: C 67.33%, H 7.45%, F 4.84%, O 20.38%
Literature References: Prepn: Edwards et al., J. Am. Chem. Soc. 82, 2318 (1960). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
 
Derivative Type: 21-Acetate
CAS Registry Number: 1597-82-6
Trademarks: Cortidene (Syntex Latino); Dilar (Cassenne); Dillar (Sarva-Syntex); Haldrate (Lilly); Haldrone (Lilly); Metilar (Syntex); Monocortin (Grñenthal); Paramezone (Recordati); Syntecort (Medicamenta); Stemex (Syntex)
Molecular Formula: C24H31FO6
Molecular Weight: 434.50
Percent Composition: C 66.34%, H 7.19%, F 4.37%, O 22.09%
Properties: mp 228-241° (dec). [a]D +85°. uv max (ethanol): 243 nm (log e 4.16). Sol in ethanol, acetone; slightly sol in water. LD50 i.p. in female rats: 392±23 mg/kg (Goldenthal).
Melting point: mp 228-241° (dec)
Optical Rotation: [a]D +85°
Absorption maximum: uv max (ethanol): 243 nm (log e 4.16)
Toxicity data: LD50 i.p. in female rats: 392±23 mg/kg (Goldenthal)
 
Derivative Type: Disodium phosphate
Trademarks: Soludillar (Syntex)
 
Derivative Type: Mixture of 21-acetate and disodium phosphate
Trademarks: Triniol (Syntex)
 
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.