Home > Name List By other > (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10, 13,16-trimethyl-7,8,12,14,15, 16-hexahydro-6H-cyclope...

CAS No 54063-32-0 , (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,
13,16-trimethyl-7,8,12,14,15,
16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione

  • Name: (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,
    13,16-trimethyl-7,8,12,14,15,
    16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
  • Synonyms: Clobetasonum [INN-Latin]; Clobetasone (INN);54063-32-0;(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,
    13,16-trimethyl-7,8,12,14,15,
    16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione; Clobetasonum; AC1L2G2H; Clobetasona [INN-Spanish]; UNII-LT69WY1J6D; Clobetasona;
  • CAS Registry Number:
  • Flash Point: 285.8°C
  • Boiling Point: 549°Cat760mmHg
  • Density: 1.32g/cm3
  • Refractive index: 1.574
  • Flash Point: 285.8°C
  • EINECS: 258-953-5
  • Molecular Weight: 408.890843
  • InchiKey: XXIFVOHLGBURIG-OZCCCYNHSA-N
  • InChI: InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,
    24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,
    10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
  • Molecular Formula: C22H26ClFO4
  • Molecular Structure:CAS No:54063-32-0 (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,<br />13,16-trimethyl-7,8,12,14,15,<br />16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione

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References of (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,
13,16-trimethyl-7,8,12,14,15,
16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Title: Clobetasone
CAS Registry Number: 54063-32-0
CAS Name: (16b)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Synonyms: 21-chloro-11-dehydrobetamethasone
Molecular Formula: C22H26ClFO4
Molecular Weight: 408.89
Percent Composition: C 64.62%, H 6.41%, Cl 8.67%, F 4.65%, O 15.65%
Literature References: Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, l973, both to Glaxo). Activity: Munro, Wilson, Br. Med. J. 3, 626 (1975). Radioimmunoassay: W. A. Webb, R. V. Brooks, Acta Endocrinol. Suppl. 212, 203 (1977). Toxicology: J. Tamura et al., J. Toxicol. Sci. 5, 45, 177 (1980). Comparative clinical studies: A. Lassus, Curr. Med. Res. Opin. 6, 165 (1979); T. Fredriksson, K. Nordin, ibid. 322. Clinical evaluation of ophthalmic form: D. Lloyd-Jones et al., Br. J. Ophthalmol. 65, 641 (1981); L. A. Eilon, S. R. Walker, ibid. 644; K. R. Wilhelmus et al., ibid. 699.
 
Derivative Type: 17-Butyrate
CAS Registry Number: 25122-57-0
Manufacturers' Codes: GR-2/1214
Trademarks: Emovate (GSK); Eumovate (GSK)
Molecular Formula: C26H32ClFO5
Molecular Weight: 478.98
Percent Composition: C 65.20%, H 6.73%, Cl 7.40%, F 3.97%, O 16.70%
Properties: Crystals from methanol, mp 90-100°.
Melting point: mp 90-100°
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.