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CAS No 5786-21-0 , 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine Search by region : Switzerland

  • Name: 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
  • Synonyms: Clorazil; Lepotex; Fazaclo; 5786-21-0; Asaleptin; CLOZARIL;Leponex; Clozapin; Iprox;3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine;
  • CAS Registry Number:
  • Transport: UN 2811 6
  • Melting Point: 182-185 ºC
  • Density: 1.31 g/cm3
  • Refractive index: 1.681
  • Water Solubility: ethanol: 1 mg/mL in water
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 227-313-7
  • Molecular Weight: 326.82326
  • InchiKey: ZUXABONWMNSFBN-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-
    13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
  • Risk Statements: S26
  • Molecular Formula: C18H19ClN4
  • Molecular Structure:CAS No:5786-21-0 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

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5786-21-0 Clozapine

  • Clozapine, 99.03%
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
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  • Fax: +41 44 805 76 77
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References of 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Title: Clozapine
CAS Registry Number: 5786-21-0
CAS Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Manufacturers' Codes: HF-1854
Trademarks: Clozaril (Novartis); Leponex (Novartis)
Molecular Formula: C18H19ClN4
Molecular Weight: 326.82
Percent Composition: C 66.15%, H 5.86%, Cl 10.85%, N 17.14%
Literature References: Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Prepn: FR 1334944 (1963 to Wander); Schmutz, Hunziker, US 3539573 (1970); NL 293201 (1965 to Wander), C.A. 64, 8221a (1966); Hunziker et al., Helv. Chim. Acta 50, 1588 (1967). Structure-activity studies: Schmutz et al., Chim. Ther. 2, 424 (1967). Pharmacology: Stille et al., Farmaco Ed. Prat. 26, 603 (1971). Metabolism: Gauch, Michaelis, ibid. 667. Toxicology: Lindt et al., ibid. 585. Review: A. C. Sayers, H. A. Amsler, in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 1-31. Review of pharmacology and clinical use: R. J. Baldessarini, F. R. Frankenburg, N. Engl. J. Med. 324, 746-754 (1991). Comprehensive description: M. J. McLeish et al., Anal. Profiles Drug Subs. Excip. 22, 145-184 (1993). Overview of mechanism of action: H. Y. Meltzer, J. Clin. Psychiatry 55, Suppl. B, 47-52 (1994). Clinical trial in suicide prevention in schizophrenia: H. Y. Meltzer et al., Arch. Gen. Psychiatry 60, 82 (2003). Review of safety and tolerability: J. Fitzsimons et al., Expert Opin. Drug Saf. 4, 731-744 (2005).
Properties: Yellow crystals from acetone-petr ether, mp 183-184°. Soly w/w at 25° (%): acetone >5; acetonitrile 1.9; chloroform >20; ethyl acetate >5; abs ethanol 4.0; water <0.01. pKa1 3.70; pKa2 7.60. Partition coefficient (octanol/water): 0.4 (pH 2); 600 (pH 7); 1000 (pH 7.4); 1500 (pH 8). uv max (ethanol): 215, 230, 261, 297 nm (e 27400, 25800, 16800, 10500). LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt).
Melting point: mp 183-184°
pKa: pKa1 3.70; pKa2 7.60
Log P: Partition coefficient (octanol/water): 0.4 (pH 2); 600 (pH 7); 1000 (pH 7.4); 1500 (pH 8)
Absorption maximum: uv max (ethanol): 215, 230, 261, 297 nm (e 27400, 25800, 16800, 10500)
Toxicity data: LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics; Serotonin-Dopamine Antagonist.