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CAS No 58-00-4 , 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-

  • Name: 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-
  • Synonyms: Ixense; Apomorphine; 6ab-Aporphine-10,11-diol (8CI);(-)-10,11-Dihydroxyaporphine; (-)-Apomorphine;Apomorphin; l-Apomorphine; Apokyn;4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (R)-; (R)-(-)-Apomorphine;4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 195 deg C (decomposes)
  • Density: 1.299 g/cm3
  • Hazard Symbols: UN NO.
  • EINECS: 200-360-0, 206-243-0
  • Molecular Weight: 303.79 .
  • InChI: InChI=1/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/p+1/t13-/m1/s1
  • Molecular Formula: C17H17 N O2
  • Molecular Structure:CAS No:58-00-4 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-
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58-00-4 APOMORPHINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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58-00-4 Apomorphine

  • Apomorphine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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58-00-4 Apomorphine

  • India Manus Aktteva []
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, ,India
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58-00-4 Apomorphine, 99%

  • Apomorphine, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
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58-00-4 (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride

  • (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochlorideApomorphine, >99%
  • United Kingdom Tocris Bioscience [Manufacturer]
  • Tel: + 44 (0)117 916 3333
  • Fax: + 44 (0)117 916 3344
  • Address: Tocris Bioscience Tocris House Hung Road BS11 9XJ BristolUNITED KINGDOM BS11 9XJ Bristol,United Kingdom
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58-00-4 Apomorphine

  • China TaiZhou HiKong Chemical Co., Ltd. []
  • Tel: +86-18967213045,13957694715
  • Fax: +86-(580)-6033180,6034626
  • Address: Taizhou Economic Technical Development Zone, Taizhou, Zhejiang 318000, ,China
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58-00-4 APOMORPHINE

  • China SINOCO CHEMICAL CO., LIMITED [Importer/Exporter]
  • Tel: +86-571-81956191, 81956192
  • Fax: 86-571-81956190 88386326
  • Address: 425 Ruiqi Mansion Moganshan Road , Hangzhou 310011 China. Hangzhou,ZhejiangChina
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58-00-4 APOMORPHINE

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58-00-4 APOMORPHINE-D3

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. ,India
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58-00-4 APOMORPHINE

  • China IFFECT CHEMPHAR CO., LTD. []
  • Tel: 0086 755-83761619 83760606
  • Fax: +86-25- 84270111
  • Address: 15A,Changfa Center, Building B ,No. 300,East Zhongshan Road,Baixia District,Nanjing,210002, P.R.China. Nanjing,JiangshuChina
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References of 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-
Title: Apomorphine
CAS Registry Number: 58-00-4
CAS Name: (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
Synonyms: 6ab-aporphine-10,11-diol
Molecular Formula: C17H17NO2
Molecular Weight: 267.32
Percent Composition: C 76.38%, H 6.41%, N 5.24%, O 11.97%
Literature References: Dopamine (D1 and D2) receptor agonist. Synthetic opiate obtained by treating morphine with concd HCl: A. Matthiessen, C. R. A. Wright, Proc. R. Soc. London Ser. B 17, 455 (1869). Structure: R. Pschorr et al., Ber. 35, 4377 (1902). Configuration: H. Corrodi, E. Hardegger, Helv. Chim. Acta 38, 2038 (1955). Total synthesis of (±)-form: J. L. Neumeyer et al., J. Pharm. Sci. 59, 1850 (1970); of (+)- and (-)-forms: V. J. Ram, J. L. Neumeyer, J. Org. Chem. 46, 2830 (1981). Toxicity data: J. Z. Ginos et al., J. Med. Chem. 18, 1194 (1975). Clinical evaluation in impotence: J. P. W. Heaton et al., Urology 45, 200 (1995). Historical review: J. L. Neumeyer et al., in Apomorphine and Other Dopaminomimetics vol. 1, G. L. Gessa, G. U. Corsini, Eds. (Raven, New York, 1981) p 1-17. Comprehensive description: F. J. Muhtadi, M. S. Hifnawy, Anal. Profiles Drug Subs. 20, 121-166 (1991). Review of pharmacology and clinical efficacy in Parkinson's disease: D. Muguet et al., Biomed. Pharmacother. 49, 197-209 (1995); in erectile dysfunction: F. Giuliano, J. Allard, Int. J. Impotence Res. 14, Suppl. 1, S53-S56 (2002).
Properties: Hexagonal plates from chloroform and petr ether, dec 195°; subl in high vacuum. Oxidizes rapidly in air and becomes green. Sol in alcohol, acetone, chloroform. Slightly sol in water, benzene, ether, petr ether. Solns darken rapidly. pKb 7.0; pKa 8.92. uv max (98% alc): 336, 399 nm.
pKa: pKb 7.0; pKa 8.92
Absorption maximum: uv max (98% alc): 336, 399 nm
 
Derivative Type: Hydrochloride
CAS Registry Number: 314-19-2; 41372-20-7 (hemihydrate)
Trademarks: Apokinon (Aguettant); Apokyn (Mylan Bertek); Apomine (Faulding); Britaject (Britannia); Ixense (Takeda); Uprima (TAP)
Molecular Formula: C17H17NO2.HCl
Molecular Weight: 303.78
Percent Composition: C 67.21%, H 5.97%, N 4.61%, O 10.53%, Cl 11.67%
Properties: Small crystals (usually hemihydrate). Dec and turn green on exposure to light and air. [a]D25 -48° (c = 1.2). uv spectrum: Csokan, Z. Anal. Chem. 124, 344 (1942). pH of aq soln (1 in 300) = 4.8. One gram dissolves in 50 ml water, 17 ml water at 80°, 50 ml alcohol. Very slightly sol in chloroform and ether. LD50 i.p. in mice: 145 mg/g (Ginos).
Optical Rotation: [a]D25 -48° (c = 1.2)
Toxicity data: LD50 i.p. in mice: 145 mg/g (Ginos)
 
Derivative Type: Diacetate (ester)
CAS Registry Number: 6191-56-6
Synonyms: Diacetylapomorphine
Molecular Formula: C21H21NO4
Molecular Weight: 351.40
Percent Composition: C 71.78%, H 6.02%, N 3.99%, O 18.21%
Properties: mp 127-128°, [a]D24 -88° (c = 1.12 in 0.1N HCl).
Melting point: mp 127-128°
Optical Rotation: [a]D24 -88° (c = 1.12 in 0.1N HCl)
 
Therap-Cat: Antiparkinsonian; emetic. In treatment of male erectile dysfunction.
Therap-Cat-Vet: Emetic.
Keywords: Antiparkinsonian; Dopamine Receptor Agonist; Emetic; Impotence Therapy.