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CAS No 58-85-5 , D-Biotin

  • Name: D-Biotin
  • Synonyms: Biotin; Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid;D-Biotin; D-Biotin pure; Vitamin B7;Vitamin H; Vitamin H (D-Biotin);
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 231-233 ºC
  • Density: 1.267 g/cm3
  • Refractive index: 90.5 ° (C=2, 0.1mol/L NaOH)
  • Alpha: 89 º (C=1, 0.1N NAOH)
  • Safety Statements: S24/25
  • Hazard Symbols: Xn
  • HS Code: 29362930
  • EINECS: 200-399-3
  • Molecular Weight: 244.31
  • InChI: InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)
  • Risk Statements: S24/25
  • Molecular Formula: C10H16N2O3S
  • Molecular Structure:CAS No:58-85-5 D-Biotin
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58-85-5 D-Biotin

  • D-Biotin Biotin (CAS: 58-85-5), also known as vitamin H or B7, has the chemical formula C10H16N2O3S (Biotin; Coenzyme R, Biopeiderm), is a water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrah...
  • China Wuhan Changland Technology Co.Ltd [Manufacturer]
  • Tel: 86-27-87290719
  • Fax: 86-27-68786490
  • Address: Changland Technology Co.,LTD Wuhan,HubeiChina
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58-85-5 D-Biotin 5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid

  • Name D-Biotin Synonyms Vitamin H; Vitamin B7; Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid Molecular Formula C10H16N2O3S Molecular Weight 244.31 CAS Registry Number 58-...
  • Min. Order: 500
  • China Suzhou 654Technology Co.,Ltd [Manufacturer]
  • Tel: 86-512-68051130
  • Fax: --
  • Address: No.32 Huoju Road , SUZHOU,JiangsuChina
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58-85-5 D(+)-Biotin

  • D(+)-Biotin
  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
    +49 (32 12) 1 00 74 76
  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany ,Germany
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58-85-5 Biotin

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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58-85-5 Vitamin H

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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58-85-5 Vitamin H

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58-85-5 D(+)-Biotin

  • D(+)-BiotinVitamin H, >99.5%
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
    Hillsborough, NJ 08844 ,United States
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58-85-5 Vitamin H

  • United States HBCChem, Inc. [Manufacturers]
  • Tel: +1-510-219-6317
  • Fax: +1-510-675-0318
  • Address: Union City,CaliforniaUnited States
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58-85-5 D-Biotin

  • D-Biotin
  • United States Chem-Impex International, Inc. [Manufacturer]
  • Tel: 630 766 2112
  • Fax: 630 766 2218
  • Address: 935 Dillon Drive Wood Dale IL 60191 USA ,United States
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58-85-5 2-(Trifluoromethyl)sulfonyl chloride

  • 2-(Trifluoromethyl)sulfonyl chloride2-(Trifluoromethyl)sulfonyl chloride, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,China
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References of D-Biotin
Title: Biotin
CAS Registry Number: 58-85-5
CAS Name: Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
Synonyms: cis-tetrahydro-2-oxothieno[3,4-d]imidazoline-4-valeric acid; cis-hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid; vitamin H; coenzyme R; bios II
Trademarks: Biodermatin (Lafare)
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31
Percent Composition: C 49.16%, H 6.60%, N 11.47%, O 19.65%, S 13.12%
Literature References: Growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue. Biotin combines with the proteinaceous substance, avidin, in raw egg-white and becomes inactive. When on diets contg large amounts of raw egg-white the rat or chick develops characteristic skin lesions and growth is retarded; these symptoms can be prevented by feeding additional biotin. Isoln from egg yolk: K?gl, T?nnis, Z. Physiol. Chem. 242, 43 (1936); from liver: Gy?rgy et al., J. Biol. Chem. 131, 745 (1939); du Vigneaud et al., ibid. 140, 643 (1941). Identity of biotin with vitamin H: du Vigneaud et al., Science 92, 62 (1940). Structure: du Vigneaud et al., J. Biol. Chem. 146, 475 (1942). First synthesis: Harris et al., J. Am. Chem. Soc. 67, 2096 (1945). Configuration: Traub, Nature 178, 649 (1956). Stereospecific total synthesis of the naturally occurring d-form: P. N. Confalone et al., J. Am. Chem. Soc. 97, 5936 (1975); eidem, J. Org. Chem. 42, 1630 (1977); T. Ogawa et al., Carbohydr. Res. 57, C31 (1977); F. G. M. Vogel et al., Ann. 1980, 1972; R. R. Schmidt, M. Maier, Synthesis 1982, 747. Synthesis of the dl-form: P. N. Confalone et al., Helv. Chim. Acta 59, 1005 (1976); M. Marx et al., J. Am. Chem. Soc. 99, 6794 (1977); A. Fliri, K. Hohenlohe-Oehringen, Ber. 113, 607 (1980); Ph. Rossy et al., Tetrahedron Lett. 22, 3493 (1981). Biosynthetic studies: R. J. Parry, M. G. Kunitani, J. Am. Chem. Soc. 98, 4024 (1976); R. J. Parry, M. V. Naidu, Tetrahedron Lett. 1980, 4783. Coordination properties: H. Siegel, Experientia 37, 789 (1981). Mechanism of action: M. J. Cravey, H. Kohn, J. Am. Chem. Soc. 102, 3928 (1980); D. L. Vesely, Science 216, 1329 (1982). Reviews: A. F. Wagner, K. Folkers, Vitamins and Coenzymes (Wiley, New York, 1964) pp 138-159; Harris in The Vitamins vol. II, W. H. Sebrell, R. S. Harris, Eds. (Academic Press, New York, 2nd ed., 1968) pp 261-359; D. B. McCormick, Nutr. Rev. 33, 97-102 (1975). Review of assay methods: P. Gy?rgy, The Vitamins vol. VII, P. Gyorgy, W. N. Pearson, Eds. (1967) pp 303-313.
Properties: Characteristics of biotin isolated from liver or milk (K?gl's b-biotin): fine long needles, mp 232-233°. [a]D21 +91° (c = 1 in 0.1N NaOH). Isoelec pt pH 3.5. pH of 0.01% aq soln 4.5. Soly at 25° (mg/100 ml): water ~22; 95% alc ~80. More sol in hot water and in dil alkali. Insol in other common organic solvents. The pure compd is stable to air and temp. Moderately acid and neutral solns are stable several months; alkaline solns are less stable, but appear reasonably stable up to a pH of about 9. Aq solns are very susceptible to mold growth. Acidic solns can be heat sterilized.
Melting point: mp 232-233°
Optical Rotation: [a]D21 +91° (c = 1 in 0.1N NaOH)
Therap-Cat: Vitamin (enzyme cofactor).
Therap-Cat-Vet: Vitamin (enzyme cofactor).
Keywords: Vitamin/Vitamin Source.