Home > Name List By p > Prostaglandin E1

CAS No 745-65-3 , Prostaglandin E1

  • Name: Prostaglandin E1
  • Synonyms: PGE1; 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid;11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid;ALPROSTADIL;Prostaglandin E1; Prostaglandin E1 or AIPROSTADIL; Alprostadil (prostandin E1);
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 115-116 ºC
  • Density: 1.131 g/cm3
  • Alpha: -64 º (C=1.0, C2H5OH)
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 212-017-2
  • Molecular Weight: 354.48
  • InChI: InChI=1/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17?,19+/m0/s1
  • Risk Statements: S36
  • Molecular Formula: C20H34O5
  • Molecular Structure:CAS No:745-65-3 Prostaglandin E1
Search by region :

Select to

745-65-3 Alprostadil

  • China N-Techem International Co.Ltd. null
  • Fax: 86-574-56707080
  • Address: Room 803, B Building, LiYuanShangDu, 39#, 158 Lane, HuanCheng XiLu, Ningbo, Zhejiang, China null,nullChina
Contact Supplier

745-65-3 Prostaglandin E1

  • China Hangzhou Yanshan Chemical Co.,Ltd [Manufacturer]
  • Tel: 86-571-86696867/ 86-571-86897279
  • Fax: 86-571-28050260
  • Address: Hangzhou Yanshan Chemical Co.,Ltd
    2/F,Block 8,No.198,Jiaogong Road,
    Hangzhou,China null,nullChina
Contact Supplier

745-65-3 Alprostadil

  • Switzerland Biotrend Chemicals AG [Importer/Exporter]
  • Tel: +41-(44)-805 76 76
  • Fax: +41-(44)-805 76 77
  • Address: Unterdorfstr. 21b, Wangen/Zuerich CH-8602, Wangen/Zürich,nullSwitzerland
Contact Supplier

745-65-3 Alprostadil

  • China Hwasun Biotechnology Co., Ltd. null
  • Fax: 86-21-64765024
  • Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China null,nullChina
Contact Supplier

745-65-3 E1-Prostaglandin

  • China Inter-Chemical Ltd. [Manufacturers]
  • Tel: +86-(755)-82187211, 82192202
  • Fax: +86-(755)-82187212
  • Address: B-1108/1109, Tian An International Bldg., RenMin Nan Road, ShenZhen 518005, Shenzhen,GuangdongChina
Contact Supplier

745-65-3 Alprostadil

Contact Supplier

745-65-3 PROSTAGLANDIN E1

  • United States Cayman Chemical Company [Manufacturer]
  • Tel: 734-975-3939; 734-975-3897 (Sales)/ 800-364-9897 (Customer Service)
  • Address: 1180 E.Ellsworth Rd.
    Ann Arbor, MI 48197
    800-364-9897 null,nullUnited States
Contact Supplier

745-65-3 Prostaglandin E1

  • Prostaglandin E1PGE1, 99% (hplc)
  • China Shanghai Benro Chemical Co.,Ltd null
  • Tel: 86-21-52178644 13917534498
  • Address: Rm602, No.689, Wuyi Road,Shanghai null,nullChina
Contact Supplier

745-65-3 Alprostadil

Contact Supplier

745-65-3 Prostaglandin E1

Contact Supplier

Select to

References of Prostaglandin E1
Title: Prostaglandin E1
CAS Registry Number: 745-65-3
CAS Name: (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid
Synonyms: 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid; alprostadil; PGE1
Manufacturers' Codes: U-10136
Trademarks: Caverject (Pharmacia & Upjohn); Edex (Schwarz); Liple (Mitsubishi); Liprostin (Endovasc); Minprog (Pharmacia); Muse (Meda); Palux (Taisho); Prostandin (Ono); Prostin VR (Pharmacia & Upjohn); Prostivas (Pharmacia & Upjohn)
Molecular Formula: C20H34O5
Molecular Weight: 354.48
Percent Composition: C 67.77%, H 9.67%, O 22.57%
Literature References: A primary prostaglandin; easily crystallized from purified biological extracts. Isoln from sheep seminal vesicle tissue, and structure: Bergstrom et al., Acta Chem. Scand. 16, 501 (1962); eidem, J. Biol. Chem. 238, 3555 (1963). Enzymic conversion from 8,11,14-eicosatrienoic acid: Nugteren et al., Rec. Trav. Chim. 85, 405 (1966). Synthesis of the dl-form: Corey et al., J. Am. Chem. Soc. 90, 3245, 3247 (1968); Schneider et al., ibid. 5895; 91, 5372 (1969); Axen et al., Chem. Commun. 1969, 303; Taub et al., ibid. 1970, 1258; Slates et al., ibid. 1972, 304; Kuo et al., Tetrahedron Lett. 1972, 5317; Taub et al., Tetrahedron 29, 1447 (1973); Miyano, Stealey, Chem. Commun. 1973, 180; Finch et al., J. Org. Chem. 38, 4412 (1973). Synthesis of natural form: Corey et al., J. Am. Chem. Soc. 91, 535 (1969); 92, 2586 (1970); Sih et al., ibid. 94, 3643 (1972); 95, 1676 (1973); Schaaf, Corey, J. Org. Chem. 37, 2921 (1974); Slates et al., Tetrahedron 30, 819 (1974). Metabolism in guinea pigs: Anggard, Samuelsson, J. Biol. Chem. 239, 4097 (1964). Metabolism in humans: Hamberg, Samuelsson, ibid. 246, 6713 (1971). Review of biological activities: Berti et al., Prog. Biochem. Pharmacol. 3, 110 (1967). Comparative pharmacology with respect to other prostaglandins: Weeks, Annu. Rev. Pharmacol. 12, 317 (1972). Clinical use in neonates with cyanotic congenital heart disease: P. M. Olley et al., Adv. Prostaglandin Thromboxane Res. 7, 913 (1980). Use in non-atherosclerotic vasculopathy: D. L. Wooster et al., J. Am. Med. Assoc. 245, 1846 (1981). Clinical trials in impotence: O. I. Linet, F. G. Ogrinc, N. Engl. J. Med. 334, 873 (1996); H. Padma-Nathan et al., ibid. 336, 1 (1997).
Properties: Crystals from ethyl acetate + heptane, mp 115-116°. [a]578 -61.6° (c = 0.56 in tetrahydrofuran). Soly at 35°: 8000 mg/100 ml double distilled water. Easily dehydrated in soln at pHs <4 or >8.
Melting point: mp 115-116°
Optical Rotation: [a]578 -61.6° (c = 0.56 in tetrahydrofuran)
Therap-Cat: Vasodilator (peripheral). In treatment of male erectile dysfunction.
Keywords: Prostaglandin/Prostaglandin Analog; Vasodilator (Peripheral).