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CAS No 768-94-5 , adamantan-1-amine

  • Name: adamantan-1-amine
  • Synonyms: 1-Aminoadamantane; 1-Adamantylamine; 768-94-5; adamantan-1-amine; Adamantylamine;1-Adamantanamine;adamantan-1-amine; Adamantanamine; Symmetrel;
  • CAS Registry Number:
  • Melting Point: 206-208 ºC
  • Density: 1.066 g/cm3
  • Refractive index: 1.557
  • Water Solubility: Soluble in organic solvents,insoluble in water.
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 212-201-2
  • Molecular Weight: 151.24868
  • InchiKey: DKNWSYNQZKUICI-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
  • Risk Statements: S26;S36
  • Molecular Formula: C10H17N
  • Molecular Structure:CAS No:768-94-5 adamantan-1-amine
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768-94-5 1-ADAMANTAMINE

  • United Kingdom Discovery Fine Chemicals [Manufacturer]
  • Tel: +44 (0)1202 874517/ +(44) (0)7894 351856 (mobile)
  • Fax: +44 (0)845 0944385
  • Address: Unit 4A - Old Forge Road
    Ferndown Industrial Estate
    Wimborne Dorset BH21 7RR
    United Kingdom null,nullUnited Kingdom
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768-94-5 amantadine

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768-94-5 amantadine

  • Netherlands Brunschwig chemie [Importer/Exporter]
  • Tel: +31 (0)20 611 31 33
  • Fax: +31 (0)20 613 75 96
  • Address: Brunschwig chemie Hexaanweg 21041 AX Amsterdam Amsterdam,AmsterdamNetherlands
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768-94-5 amantadine

  • China Meryer Chemical Technology Co., Ltd [Manufacturers]
  • Tel: +86-(0)755-86170218
  • Fax: +86-(0)755-86170066
  • Address: Room 23A, Building 4, Fashion House,Chuangye Road, Nanshan District shenzhen,shenzhenChina
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768-94-5 AMANTADINE

  • China Levachem Co. Ltd. [Manufacturers]
  • Tel: 86-25-83247442 / 443 / 445 / 446 / 447
  • Fax: +86-25-83247441
  • Address: 2112, SuNing Universal Mansion, 188 Guangzhou Road, Nanjing-210024, China Nanjing,jiangsuChina
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768-94-5 1-ADAMANTYLAMINE

  • Germany Intatrade Chemicals GmbH [Manufacturer]
  • Tel: +49 3493/605464
  • Fax: +49 3493/605470
  • Address: Intatrade Chemicals GmbH
    Vierzoner Strasse 14
    D-06749 Bitterfeld, Germany null,nullGermany
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768-94-5 amantadine

  • China HUNAN OUYA BIOLOGICAL CO.,LTD [Manufacturers]
  • Tel: +86-592-5789919
  • Fax: +86-592-5637388
  • Address: Changsha National Biomedical Industrial Base Changsha,HunanChina
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768-94-5 Amantadine

  • China Suntin MediPharma Co. Ltd. [Importer/Exporter]
  • Tel: +86 755 8386 5062 ; +852 2690 9351
  • Fax: +86 755 8386 4173 ; +852 2690 9356
  • Address: RM.2501-2502, 25/F., Convention & Exhibition Times Center, 3008 Yitian RD., Shenzhen China. null,nullChina
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768-94-5 1-ADAMANTANAMINE, 99%

  • United States Dudley Chemical Corp. [Manufacturer]
  • Tel: (732) 886-3100
  • Fax: (732) 886-3688
  • Address: Dudley Chemical Corp.
    125 Kenyon Drive
    Lakewood, NJ 08701 null,nullUnited States
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768-94-5 amantadine

  • Austria Loba Feinchemie AG [Manufacturers]
  • Tel: ++43 (0)2232 77391-0 ++43 (0)2232 / 77391-21
  • Fax: ++43 (0)2232 76677
  • Address: Fehrgasse 7, 2401 Fischamend, Austria Fischamend,FischamendAustria
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References of adamantan-1-amine
Title: Amantadine
CAS Registry Number: 768-94-5
CAS Name: Tricyclo[3.3.1.13,7]decan-1-amine
Synonyms: 1-adamantanamine; 1-aminoadamantane; 1-aminodiamantane (obsolete); 1-aminotricyclo[3.3.1.13,7]decane
Molecular Formula: C10H17N
Molecular Weight: 151.25
Percent Composition: C 79.41%, H 11.33%, N 9.26%
Literature References: NMDA-receptor antagonist; also active vs influenza A virus. Prepn: H. Stetter et al., Ber. 93, 226 (1960); W. Haaf, ibid. 97, 3234 (1964); P. Kovacic, P. D. Roskos, Tetrahedron Lett. 1968, 5833. Antiviral activity: W. L. Davies et al., Science 144, 862 (1964). GC determn in biological samples and pharmacodynamics: W. E. Bleidner et al., J. Pharmacol. Exp. Ther. 150, 484 (1965). Pharmacology and toxicology: V. G. Vernier et al., Toxicol. Appl. Pharmacol. 15, 642 (1969). Comprehensive description: J. Kirschbaum, Anal. Profiles Drug Subs. 12, 1-36 (1983). Review of use vs influenza A: R. L. Tominack, F. G. Hayden, Infect. Dis. Clin. North Am. 1, 459-478 (1987); of pharmacokinetics: F. Y. Aoki, D. S. Sitar, Clin. Pharmacokinet. 14, 35-51 (1988). Review of NMDA receptor binding and neuroprotective properties: J. Kornhuber et al., J. Neural Transm. 43, Suppl., 91-104 (1994). Series of articles on clinical experience in Parkinson's disease: ibid. 46, Suppl., 399-421 (1995).
Properties: Crystals by sublimation, mp 160-190° (closed tube) (Stetter). Also reported as mp 180-192° (Haaf). pKa: 10.1. Sparingly sol in water.
Melting point: mp 160-190° (closed tube) (Stetter); mp 180-192° (Haaf)
pKa: pKa: 10.1
 
Derivative Type: Hydrochloride
CAS Registry Number: 665-66-7
Manufacturers' Codes: EXP-105-1; NSC-83653
Trademarks: Adekin (Desitin); Lysovir (Alliance); Mantadan (Boehringer, Ing.); Mantadine (Endo); Mantadix (BMS); Symmetrel (Endo); Virofral (Novo)
Molecular Formula: C10H17N.HCl
Molecular Weight: 187.71
Percent Composition: C 63.99%, H 9.67%, N 7.46%, Cl 18.89%
Properties: Crystals from abs ethanol + anhydr ether, mp >360° (dec). Freely sol in water (at least 1:20); sol in alcohol, chloroform. Practically insol in ether. LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier).
Melting point: mp >360° (dec)
Toxicity data: LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier)
 
Derivative Type: Sulfate
CAS Registry Number: 31377-23-8
Trademarks: PK-Merz (Merz)
Molecular Formula: C10H17N.?H2SO4
Molecular Weight: 200.29
Percent Composition: C 59.97%, H 9.06%, N 6.99%, S 8.00%, O 15.98%
 
Therap-Cat: Antiviral; antiparkinsonian.
Keywords: Antidyskinetic; Antiparkinsonian; Antiviral.