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CAS No 768-94-5 , adamantan-1-amine

  • Name: adamantan-1-amine
  • Synonyms: 1-Aminoadamantane; 1-Adamantylamine; 768-94-5; adamantan-1-amine; Adamantylamine;1-Adamantanamine;adamantan-1-amine; Adamantanamine; Symmetrel;
  • CAS Registry Number:
  • Melting Point: 206-208 ºC
  • Density: 1.066 g/cm3
  • Refractive index: 1.557
  • Water Solubility: Soluble in organic solvents,insoluble in water.
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 212-201-2
  • Molecular Weight: 151.24868
  • InchiKey: DKNWSYNQZKUICI-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
  • Risk Statements: S26;S36
  • Molecular Formula: C10H17N
  • Molecular Structure:CAS No:768-94-5 adamantan-1-amine
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768-94-5 amantadine

  • Japan Shigematsu & Co., Ltd [Manufacturers]
  • Tel: (06) 6231-6146
  • Fax: (06) 6231-6149
  • Address: 2-5 Awaji-machi 2 Chome , Chuo-ku Osaka , Japan Zip# 541-0047 Chuo-ku,OsakaJapan
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768-94-5 Amantadine

  • Amantadine: 1)used to make antivirus medicine 2)treating A2 type flu virus,anaesthesia of Parkinson's symptom disease Amantadine: used to make antivirus medicine for treating A2 type flu virus,anaesthesia of Parkinson's symptom disease. Appearance: W...
  • China Daxinganling zhongbei bio-chemical [Manufacturers]
  • Tel: 86-452-6197192
  • Fax: 0086 452 6197939
  • Address: 5F, C Liandalijing Bulding,No 259 Xinjiang Road, Jianhua District Qiqiha'er,HeilongjiangChina
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768-94-5 amantadine

  • China Waycome Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: 023-74578888/13603071098
  • Fax: 023-74577298
  • Address: No. 138 YuWu Road, XinMin Town, DianJiang 408302, chonqing,china chonqing,chonqingChina
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768-94-5 Amantadine

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768-94-5 1-Adamantanamine

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768-94-5 1-Adamantanamine

  • China Hallochem Pharma Co.,Ltd. [Manufacturer]
  • Tel: +86-23-67030808-8820
  • Fax: +86-23-67030809
  • Address: Hallochem Pharma Co.,Ltd.
    17F, Venus Science
    Incubate Center,
    No.60 Xingguang Road,
    New North Zone,Chongqing
    China null,nullChina
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768-94-5 Amantadine

  • China Jiangxi Dongtai Technology Co., Ltd. null
  • Fax: 86-791-7539377
  • Address: Room 409, Ziyou Du, 93#, Qingshan South Road, Donghu District, Nanchang, Jiangxi Province, China null,nullChina
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768-94-5 amantadine

  • China Luzhou Wanlian Chemical Co.,Ltd. [Manufacturers]
  • Tel: +86-830-3115236
  • Fax: 86-830-3115236/3193335
  • Address: 5-7# Qianjinxia Rd,Luzhou,Sichuan,P.R.C. Luzhou,SichuanChina
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768-94-5 1-ADAMANTYLAMINE

  • United States International Specialty Chemicals, Inc. [Manufacturer]
  • Tel: (914) 333-0606
  • Fax: (914) 333-0333
  • Address: International Specialty Chemicals, Inc.
    303 South Broadway Suite: 425
    Tarrytown, New York 10591 USA null,nullUnited States
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768-94-5 AMANTADINE

  • China TCS INDUSTRY LTD [Manufacturer]
  • Tel: 86-0512-50326221/ 86-0512-50226427
  • Fax: 86-0512-50326221
  • Address: TCS INDUSTRY LTD
    NO.88 South of Changjiang Road,
    Kunshan city, Jiangsu Province,
    215300 CHINA null,nullChina
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References of adamantan-1-amine
Title: Amantadine
CAS Registry Number: 768-94-5
CAS Name: Tricyclo[3.3.1.13,7]decan-1-amine
Synonyms: 1-adamantanamine; 1-aminoadamantane; 1-aminodiamantane (obsolete); 1-aminotricyclo[3.3.1.13,7]decane
Molecular Formula: C10H17N
Molecular Weight: 151.25
Percent Composition: C 79.41%, H 11.33%, N 9.26%
Literature References: NMDA-receptor antagonist; also active vs influenza A virus. Prepn: H. Stetter et al., Ber. 93, 226 (1960); W. Haaf, ibid. 97, 3234 (1964); P. Kovacic, P. D. Roskos, Tetrahedron Lett. 1968, 5833. Antiviral activity: W. L. Davies et al., Science 144, 862 (1964). GC determn in biological samples and pharmacodynamics: W. E. Bleidner et al., J. Pharmacol. Exp. Ther. 150, 484 (1965). Pharmacology and toxicology: V. G. Vernier et al., Toxicol. Appl. Pharmacol. 15, 642 (1969). Comprehensive description: J. Kirschbaum, Anal. Profiles Drug Subs. 12, 1-36 (1983). Review of use vs influenza A: R. L. Tominack, F. G. Hayden, Infect. Dis. Clin. North Am. 1, 459-478 (1987); of pharmacokinetics: F. Y. Aoki, D. S. Sitar, Clin. Pharmacokinet. 14, 35-51 (1988). Review of NMDA receptor binding and neuroprotective properties: J. Kornhuber et al., J. Neural Transm. 43, Suppl., 91-104 (1994). Series of articles on clinical experience in Parkinson's disease: ibid. 46, Suppl., 399-421 (1995).
Properties: Crystals by sublimation, mp 160-190° (closed tube) (Stetter). Also reported as mp 180-192° (Haaf). pKa: 10.1. Sparingly sol in water.
Melting point: mp 160-190° (closed tube) (Stetter); mp 180-192° (Haaf)
pKa: pKa: 10.1
 
Derivative Type: Hydrochloride
CAS Registry Number: 665-66-7
Manufacturers' Codes: EXP-105-1; NSC-83653
Trademarks: Adekin (Desitin); Lysovir (Alliance); Mantadan (Boehringer, Ing.); Mantadine (Endo); Mantadix (BMS); Symmetrel (Endo); Virofral (Novo)
Molecular Formula: C10H17N.HCl
Molecular Weight: 187.71
Percent Composition: C 63.99%, H 9.67%, N 7.46%, Cl 18.89%
Properties: Crystals from abs ethanol + anhydr ether, mp >360° (dec). Freely sol in water (at least 1:20); sol in alcohol, chloroform. Practically insol in ether. LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier).
Melting point: mp >360° (dec)
Toxicity data: LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier)
 
Derivative Type: Sulfate
CAS Registry Number: 31377-23-8
Trademarks: PK-Merz (Merz)
Molecular Formula: C10H17N.?H2SO4
Molecular Weight: 200.29
Percent Composition: C 59.97%, H 9.06%, N 6.99%, S 8.00%, O 15.98%
 
Therap-Cat: Antiviral; antiparkinsonian.
Keywords: Antidyskinetic; Antiparkinsonian; Antiviral.