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CAS No 7689-03-4 , (+)-Camptothecin

  • Name: (+)-Camptothecin
  • Synonyms: (+)-Camptothecine; d-Camptothecin; (S)-Camptothecin; 20(S)-Camptothecine;Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; (+)-Camptothecin;(+)-Camptothecin;
  • CAS Registry Number:
  • Transport: UN 1544
  • Melting Point: 260 ºC
  • Density: 1.51 g/cm3
  • Refractive index: 1.787
  • Safety Statements: R25
  • Hazard Symbols: T: Toxic;
  • EINECS: 444-280-6
  • Molecular Weight: 348.35204
  • InchiKey: VSJKWCGYPAHWDS-FQEVSTJZSA-N
  • InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-
    22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
  • Risk Statements: S26;S36/37/39;S45
  • Molecular Formula: C20H16N2O4
  • Molecular Structure:CAS No:7689-03-4 (+)-Camptothecin
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7689-03-4 Camptothecin

  • Product Name: Camptothecin CAS No.: 7689-03-4 MDL Number: MFCD00081076 Jingyu Number: C1 Chemical name: (S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline -3,14(4H,12H)-dione Formula: C20H16N2O4 Formula Weight: 348.35 Appearance: Pal...
  • Min. Order: 50
  • China Sichuan JingYu Chemical Co., Ltd. [Manufacturer]
  • Tel: 86-28-38030091
  • Fax: 86-28-38030092
  • Address: No.268, Peicheng Road, DoPo Distric Meishan,SichuanChina
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7689-03-4 (+)-Camptothecin

  • Ourcompany produced this products, and in stock now. Our advantage products are Adamantane derivatives, Aromatic compounds derivatives, Pharmaceutical intermediates etc. We offer the services of Laboratory custom synthesis and the services of factory...
  • Min. Order: 100
  • China Shanghai B&C Chemic Co.Ltd [Manufacturer, Trading Company]
  • Tel: 86-021-37895188
  • Address: Building No.9 No. 1158 Zhongxin Rd. Shanghai P.R. China Shanghai,ShanghaiChina
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7689-03-4 Camptothecin

  • Camptothecin Synonym: 1,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE;(20S)-CAMPTOTHECIN;4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE;5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA...
  • Min. Order: 500
  • China Wuhan Yuancheng Group [Manufacturer, Trading Company]
  • Tel: 86-027-50756153
  • Address: Zhongshan Road Wuhan,HubeiChina
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7689-03-4 Camptothecine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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7689-03-4 Camptothecin

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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7689-03-4 Camptothecine

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7689-03-4 Camptothecine

  • United States HBCChem, Inc. [Manufacturers]
  • Tel: +1-510-219-6317
  • Fax: +1-510-675-0318
  • Address: Union City,CaliforniaUnited States
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7689-03-4 Camptothecin

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
  • Fax: +86-21-61044583
  • Address: 1-102,No.11,Dongjiaominxiang Alley,
    Dongcheng District,
    Beijing 100005,China ,China
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7689-03-4 Camptothecin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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7689-03-4 Camptothecin

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References of (+)-Camptothecin
Title: Camptothecin
CAS Registry Number: 7689-03-4
CAS Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3¢,4¢:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Formula: C20H16N2O4
Molecular Weight: 348.35
Percent Composition: C 68.96%, H 4.63%, N 8.04%, O 18.37%
Literature References: Antitumor alkaloid; prototype DNA topoisomerase I inhibitor. Isoln from the stem wood of the Chinese tree, Camptotheca acuminata Decsne., Nyssaceae, and structure: M. E. Wall et al., J. Am. Chem. Soc. 88, 3888 (1966). Approach to synthesis: Kepler et al., J. Org. Chem. 34, 3853 (1969). Total synthesis: E. J. Corey et al., ibid. 40, 2140 (1975). Total synthesis of racemate: Stork, Schultz, J. Am. Chem. Soc. 93, 4074 (1971); Volkmann et al., ibid. 5576; Tang et al., ibid. 97, 159 (1975); J. C. Bradley, G. Buchi, J. Org. Chem. 41, 699 (1976); T. Kametani et al., J. Chem. Soc. Perkin Trans. 1 1981, 1563. Pharmacologic and clinical evaluation: Gottlieb et al., Cancer Chemother. Rep. Part 1 54, 461 (1970); Gallo et al., J. Natl. Cancer Inst. 46, 789 (1971); S. M. Sieber et al., Cancer Treat. Rep. 60, 1127 (1976). Mechanism of action: Y. H. Hsiang et al., J. Biol. Chem. 260, 14873 (1985). HPLC determn in plasma: J. H. Beijnen et al., J. Chromatogr. 617, 111 (1993). Reviews: M. Potmesil, Cancer Res. 54, 1431-1439 (1994); M. E. Wall, M. C. Wani, ibid. 55, 753-760 (1995).
Properties: Pale yellow needles from methanol + acetonitrile, dec 264-267°. Also reported as mp 275-277° (Volkmann); 287-288° (Stork, Schultz). [a]D25 +31.3° (in chloroform-methanol, 8:2). Exhibits intense blue fluorescence under uv light. uv max: 220, 254, 290, 370 nm (e 37320, 29230, 4980, 19900). Does not form stable salts with acids. Poorly sol in water.
Melting point: mp 275-277° (Volkmann); 287-288° (Stork, Schultz)
Optical Rotation: [a]D25 +31.3° (in chloroform-methanol, 8:2)
Absorption maximum: uv max: 220, 254, 290, 370 nm (e 37320, 29230, 4980, 19900)
 
Derivative Type: Acetate
Molecular Formula: C22H18N2O5
Molecular Weight: 390.39
Percent Composition: C 67.68%, H 4.65%, N 7.18%, O 20.49%
Properties: Crystals, dec 271-274°. uv max: 220, 254, 290, 360-370 nm (e 39010, 28740, 6160, 22000).
Absorption maximum: uv max: 220, 254, 290, 360-370 nm (e 39010, 28740, 6160, 22000)
 
Derivative Type: Chloroacetate
Molecular Formula: C22H17ClN2O5
Molecular Weight: 424.83
Percent Composition: C 62.20%, H 4.03%, Cl 8.35%, N 6.59%, O 18.83%
Properties: Crystals, dec 245-248°.