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CAS No 835-31-4 , 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole

  • Name: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
  • Synonyms: Nafazolina [DCIT]; Nafazoline [Spanish]; Antan; Clearine; 1H-Imidazole; 835-31-4; 4,5-dihydro-2-(1-naphthalenylmethyl)-;Naphthizine;2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 2
  • Melting Point: 254 °C
  • Flash Point: 220.2 ºC
  • Boiling Point: 440.5 ºC at 760 mmHg
  • Density: 1.15g/cm3
  • Refractive index: 1.64
  • Safety Statements: Poison by subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T: Toxic;
  • Flash Point: 220.2 ºC
  • EINECS: 212-641-5
  • Molecular Weight: 210.27436
  • InchiKey: CNIIGCLFLJGOGP-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,
    8-10H2,(H,15,16)
  • Risk Statements: 25
  • Molecular Formula: C14H14N2
  • Molecular Structure:CAS No:835-31-4 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
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835-31-4 naphazoline

  • IUPAC NAME-2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole MOLECULAR FORMULA-C14H14N2 MOLAR MASS-210.274
  • India Swapnroop Drugs and Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
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  • Address: Harsool aurangabad,maharashtraIndia
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835-31-4 Naphazoline

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835-31-4 Nafazoline

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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835-31-4 1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-

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835-31-4 1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-

  • China Hangzhou Starshine Pharmaceutical Co., LTD [Manufacturers]
  • Tel: +86-571-89939756 85122191
  • Fax: +86-571-85122157
  • Address: ROOM A, 20 TH FLOOR, WEST BUILDING, INTERNATIONAL GARDEN, NO.160 TIANMUSHAN ROAD, HANGZHOU, CHINA ,ZhejiangChina
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835-31-4 1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-

  • China VETCHEM Biochemistry Science [, Manufacturer, Distributor/Wholesaler]
  • Tel: +86-21-593837
  • Address: No.2 Jinshanwei Industrial Zon,Shanghai 200120 China Shanghai,ShanghaiChina
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835-31-4 1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-

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835-31-4 1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-

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835-31-4 Naphazoline

  • Naphazoline CAS Number:835-31-4 Molecular Formula:C14H14N2 Molecular Weight:210.30
  • China Wuhan Yuancheng Gongchuang Technology Co., Ltd. [Manufacturer]
  • Tel: 86-27-88310829
  • Fax: 86-27-88064757
  • Address: 496#, zhongshan road, wuhan wuhan,China
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References of 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Title: Naphazoline
CAS Registry Number: 835-31-4
CAS Name: 4,5-Dihydro-2-(1-naphthalenylmethyl)-1H-imidazole
Synonyms: 2-(1-naphthylmethyl)imidazoline
Molecular Formula: C14H14N2
Molecular Weight: 210.27
Percent Composition: C 79.97%, H 6.71%, N 13.32%
Literature References: a-Adrenergic agonist. Prepd by reacting the acetic acid anhydride of naphthoimidic acid with ethylenediamine: A. Sonn, US 2161938 (1939 to Soc. Chem. Ind. Basle); by reacting naphthylthioacetamide with ethylenediamine: DK 62889 (1944 to Lovens Kemiske), C.A. 40, 4398 (1946). Toxicity data: J. Gylfe et al., Fed. Proc. 9, 280 (1950). Comprehensive description: G. M. Wall, Anal. Profiles Drug Subs. Excip. 21, 307-344 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 550-99-2
Trademarks: Ak-Con (Akorn); Albalon (Allergan); Clera (Person & Covey); Coldan; Iridina Due (Montefarmaco); Naphcon (Alcon); Niazol; Opcon (Bausch & Lomb); Privine (Novartis); Rhinantin; Rhinoperd; Sanorin; Sanorin-Spofa; Strictylon
Molecular Formula: C14H14N2.HCl
Molecular Weight: 246.74
Percent Composition: C 68.15%, H 6.13%, N 11.35%, Cl 14.37%
Properties: Bitter crystals, mp 255-260°. uv max (ethanol): 223, 270, 280, 287, 291 nm (E1%1cm 3622, 239, 286, 196, 198). pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03. pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03. Freely sol in water (40 g dissolve in 100 ml) and in alcohol. Slightly sol in chloroform. Insol in benzene, ether. A 1% aq soln has a pH of ~6.2. LD50 s.c. in rats: 385 mg/kg (Gylfe).
Melting point: mp 255-260°
pKa: pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03; pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03
Absorption maximum: uv max (ethanol): 223, 270, 280, 287, 291 nm (E1%1cm 3622, 239, 286, 196, 198)
Toxicity data: LD50 s.c. in rats: 385 mg/kg (Gylfe)
 
Therap-Cat: Adrenergic (vasoconstrictor); decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.