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CAS No 84-79-7 , 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione

  • Name: 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
  • Synonyms: Taigu wood; 84-79-7; Greenhartin; IPE-tobacco wood; Lapachol wood; Taiguic acid; Bethabarra wood;Tecomin;4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione;
  • CAS Registry Number:
  • Melting Point: 141-143 ºC(lit.)
  • Flash Point: 209 ºC
  • Boiling Point: 398.6 ºC at 760 mmHg
  • Density: 1.235 g/cm3
  • Refractive index: 1.606
  • Safety Statements: 26-36
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 209 ºC
  • EINECS: 201-563-7
  • Molecular Weight: 242.26986
  • InchiKey: CWPGNVFCJOPXFB-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/
    h3-7,16H,8H2,1-2H3
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C15H14O3
  • Molecular Structure:CAS No:84-79-7 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
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84-79-7 LAPACHOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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84-79-7 Lapachol

  • Lapachol2-Hydroxy-3-(3-methylbut-2-enyl)-1,4-naphthoquinone
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
    Hillsborough, NJ 08844 ,United States
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84-79-7 Lapachol

  • Lapachol, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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84-79-7 LAPACHOL(RG)

  • LAPACHOL(RG)Lapachol
  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 ,United States
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84-79-7 Lapachol

  • Lapachol2-Hydroxy-3-(3-methylbut-2-enyl)
  • China Beijing HuameiHuli Biochem Ltd [Manufacturers]
  • Tel: 010-86181995
  • Fax: 010-86860610
  • Address: Beijing TongZhou District Beijing,BeijingChina
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84-79-7 1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

  • China Modachem Shanghai Co., Ltd. [Manufacturers]
  • Tel: 021-51371369
  • Fax: 021-51371369
  • Address: zhangjiang, Shanghai 200230, P.R.China shanghai,shanghaiChina
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84-79-7 LAPACHOL

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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84-79-7 1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

  • China Suzhou Southeast Pharmaceuticals,Inc [Manufacturers]
  • Tel: +86-512-6272 9923
  • Fax: +86-512-6272 9923
  • Address: C316 Room,150 RenAi Road,Suzhou industrial park,P.R.China Suzhou,JiangsuChina
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84-79-7 1,4-Naphthalenedione,2-hydroxy-3-(3-methyl-2-buten-1-yl)-

  • Brazil PVP Sociedade Anonima [Importer/Exporter]
  • Tel: + 55-86-33158015
  • Fax: + 55-86-3158006 or 3158007
  • Address: Rua Jo閴?Em闊慽o Falc閴?Costa, 14864218-290 Parna闊嘺 (PI) - Brasil Costa,ParnaíbaBrazil
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84-79-7 Lapachol

  • Lapachol
  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
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References of 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
Title: Lapachol
CAS Registry Number: 84-79-7
CAS Name: 2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione
Synonyms: lapachic acid; taiguic acid; tecomin; greenhartin
Manufacturers' Codes: NSC-11905
Molecular Formula: C15H14O3
Molecular Weight: 242.27
Percent Composition: C 74.36%, H 5.82%, O 19.81%
Literature References: Yellow crystalline material derived from the heartwood of Asian and South American bignoniaceous plants, esp Surinam greenheart, Taigu wood, Lapacho heartwood and Bethabarra wood: Arnoudon, Compt. Rend. 41, 1152 (1857); Stein, J. Prakt. Chem. 99, 1 (1866); Paterno, Gazz. Chim. Ital. 9, 506 (1879); Greene, Hooker, Am. Chem. J. 11, 267 (1889). Structure: Paterno, Gazz. Chim. Ital. 12, 337 (1882); Hooker J. Chem. Soc. 61, 611 (1892); 69, 1355 (1896); J. Am. Chem. Soc. 58, 1168 (1936). Synthesis: Fieser, ibid. 49, 857 (1927); Hooker, ibid. 58, 1181 (1936); G. R. Pettit, L. E. Houghton, J. Chem. Soc. C 1971, 509. Although it is related structurally to vitamin K, q.v., it does not possess antihemorrhagic activity: H. J. Almquist, A. A. Klose, J. Am. Chem. Soc. 61, 1923 (1939); L. F. Fieser et al., J. Biol. Chem. 137, 659 (1941). It is reported to be an inhibitor of respiratory processes: E. G. Ball et al., ibid. 168, 257 (1947). Lapachol has also exhibited antitumor activity vs Walker 256 carcinoma: K. V. Rao et al., Proc. Am. Assoc. Cancer Res. 8, 55 (1967). Mass spectrometry: T. A. Elwood et al., Org. Mass Spectrom. 3, 841 (1970). Chromatographic detection: M. H. Simatupang et al., J. Chromatogr. 52, 180 (1970). Pharmacology: S. M. Sieber et al., Cancer Treat. Rep. 60, 1127 (1976). Toxicity study: R. K. Morrison et al., Toxicol. Appl. Pharmacol. 17, 1 (1970). Review of antitumor activity: K. V. Rao, Cancer Chemother. Rep. Part 2 4 (4), 11-17 (1974).
Properties: Yellow prisms from alcohol or ether, mp 140°. uv max: 251.5, 278, 331 nm (log e 4.38, 4.28, 3.43). Soluble in alcohol, chloroform, benzene, acetic acid, slightly sol in ether, hot water. Sol in aq NaOH solns forming a bright red sodium salt. LD50 in male, female BALB/c mice (g/kg): 0.487; 0.792 orally (Morrison).
Melting point: mp 140°
Absorption maximum: uv max: 251.5, 278, 331 nm (log e 4.38, 4.28, 3.43)
Toxicity data: LD50 in male, female BALB/c mice (g/kg): 0.487; 0.792 orally (Morrison)