Y-27632 (dihydrochloride)

• Product NameY-27632 (dihydrochloride)
  CAS No.129830-38-2
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

Y-27632 (dihydrochloride)Y-27632 2Hcl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

IC50 value: 140 nM (Ki)

Target: ROCK1

in vitro: Y-27632 inhibits ROCK-II while displaying little activity against PKC, cAMP-dependent protein kinase and myosin light-chain kinase (MLCK) with Ki of 26 μM, 25 μM and > 250 μM, respectively, as well as PKA activated by another Rho-family GTPase member, Cdc42.

Target:Antibacterial

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