MK-4827

• Product NameMK-4827
  CAS No.1038915-60-4
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

MK-4827MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

IC50 value: 3.8 nM/2.1 nM( PARP1/2) [1]

Target: PARP1/2

in vitro: MK-4827 displays excellent PARP 1 and 2 inhibition with IC(50) = 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibits PARP activity with EC(50) = 4 nM and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC(50) in the 10-100 nM range [1].

Target:Glucokinase

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