Vardenafil

• Product NameVardenafil
  CAS No.224785-91-5
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  Molecular Structure

Detailed Description

Quick Detail:

Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.



Description:

Vardenafil
Alias: Levitra;Fardenafil
CAS No: 224785-91-5
MF: C23H33ClN6O4S
MW: 525.06
Purity: 99%
Appearance: white powder, odorless, taste bitter and astringent soluble in water and alcohol.

Applications:

Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from vaginal penetration to ejaculation. Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).
Further, Vardenafil causing lengthening of the QT interval. Therefore it should not be taken by men taking other medications that affect the QT interval (such as amiodarone).


Specifications:

Test Items Specification Test Results
Description White or almost white crystalline powder White crystalline powder
Melting Point 191.0～193.0℃ 192℃
Loss of drying ≤1.0% 0.5%
Heavy Metal ≤20ppm 15ppm
TLC Only one spot Only one spot
Assay ≥99.5% 99.91%
Conclusion It complies with the USP 32.

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