Home > Name List By d > Docetaxel

CAS No 114977-28-5 , Docetaxel

  • Name: Docetaxel
  • Synonyms: Docetaxel;Taxotere; Trihydrate; 114977-28-5; CHEBI:4672; Docetaxel; Taxotere (TN); EmDOC; Taxotere(R); Docetaxel anhydrous;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 232 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.618
  • Alpha: -36 º (C=0.74,ETOH)
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 807.87922
  • InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • InChI: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38
    (52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,
    34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,
    26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,
    32+,33-,35-,41+,42-,43+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H53NO14
  • Molecular Structure:CAS No:114977-28-5 Docetaxel

Related products

Search by region :

Select to

114977-28-5 Taxotere

  • China Haiqiang Chemicals Co., Ltd [Manufacturers]
  • Tel: +86-571-86465881
  • Fax: +86-571-86414728
  • Address: No.407 Tianyuange, No.218 Daomao Xiang, Hangzhou City, Zhejiang Province, China. Hangzhou,ZhejiangChina
Contact Supplier

114977-28-5 Taxotere

  • China Hangzhou Hysen Pharma Co.,Ltd [Manufacturers]
  • Tel: 0571-89937472
  • Fax: 0571-89937386
  • Address: ROOM 808, C# Zi Jin PLAZA , NO. 701, Gu'Dun ROAD hangzhou,zhejiangChina
Contact Supplier

114977-28-5 DOCETAXEL

  • China AFINE CHEMICALS LIMITED [Manufacturer]
  • Tel: +86-571-85134551/ +86-571-85232125
  • Fax: +86-571-85134895
  • Address: AFINE CHEMICALS LIMITED
    7-C-601, Xi Gang Xin Jie,
    Xihu Industrial Park,
    No. 206 Zhen Hua Road,Hangzhou
    310030, Zhejiang, China null,nullChina
Contact Supplier

114977-28-5 Docetaxol

  • Docetaxol, 99.0%min
  • China Lemman Laboratories International Co., Ltd. [Importer/Exporter]
  • Tel: +86-(571)-8697-7060
  • Fax: +86-(571)-8697-6607
  • Address: Room 223, Tianhu Blng, No.79 Jiaogong Road, Hangzhou, Zhejiang, hangzhou,zhejaingChina
Contact Supplier

114977-28-5 DOCETAXEL

  • China Hangzhou Verychem Science And Technology Co., Ltd. [Manufacturer]
  • Tel: +86-571-8816 2785/ +86-571-8816 2786
  • Fax: +86-571-8816 2787
  • Address: Hangzhou Verychem Science And Technology Co., Ltd.
    1108A,316 Jiaogong Road,
    Hangzhou City,
    Zhejiang Province, China
    Post Code: 310012 null,nullChina
Contact Supplier

114977-28-5 Docetaxel

  • China Advan Pharmachem Co., Ltd. [Manufacturers]
  • Tel: +86-(21)-6875-3906, 5058-1635
  • Fax: +86-(21)-5831-8593
  • Address: Room 1418 YuAn Mansion, No.738 Dongfang Road, Pu Dong, Shanghai, shanghai,shanghaiChina
Contact Supplier

114977-28-5 Docetaxel-Botanical reference materials/phytochemicals

  • Docetaxel-Botanical reference materials/phytochemicals
  • China shanghai Tauto Biotech Co., Ltd [Manufacturer]
  • Tel: +86-21-51320588
  • Fax: +86-21-51320502
  • Address: No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA Shanghai,ShanghaiChina
Contact Supplier

114977-28-5 Docetaxel

Contact Supplier

114977-28-5 Docetaxel

  • Docetaxel product Name: Docetaxel CAS Registry Number: 114977-28-5 Assays: 99.5% Packaging: 10g/bag Molecular Formula: C43H53NO14 Molecular Weight: 807.88 Appearance: White crystalline powder Usage: Chemotherapy for early failure of treatment of adva...
  • China Wuhan YuanCheng Gongchuang Technology Co., Ltd. [Manufacturer]
  • Tel: 86-27-88083115
  • Fax: 86-27-88048077
  • Address: 496, Zhongshan Road, Wuchang, Wuhan, China Wuhan,HubeiChina
Contact Supplier

114977-28-5 DOCETAXEL

  • China Enze Chemicals Co.,Ltd [Manufacturer]
  • Tel: +(86)-(571)-8865-5925/ +86-013750849205 (mobile)
  • Fax: +(86)-(571)5627-7156
  • Address: Industry develop area Meicheng Town,
    Jiande, H/Z, China null,nullChina
Contact Supplier

Select to

12/26
Previous 8 9 10 11 12 13 14 15 16 17 Next
References of Docetaxel
Title: Docetaxel
CAS Registry Number: 114977-28-5
CAS Name: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Manufacturers' Codes: NSC-628503; RP-56976
Trademarks: Taxotere (Aventis)
Molecular Formula: C43H53NO14
Molecular Weight: 807.88
Percent Composition: C 63.93%, H 6.61%, N 1.73%, O 27.73%
Literature References: Semisynthetic derivative of paclitaxel, q.v., prepd using a natural precursor, 10-deacetylbaccatin III, extracted from the needles of the European yew tree, Taxus baccata L., Taxaceae. Antimitotic agent that promotes the assembly of microtubules and inhibits their depolymerization to free tubulin. Prepn: M. Colin et al., EP 253738; eidem, US 4814470 (1988, 1989 both to Rh?ne-Poulenc Sante); L. Mangatal et al., Tetrahedron 45, 4177 (1989). Synthesis of the side chain: J.-N. Denis et al., J. Org. Chem. 56, 6939 (1991). Structure-activity study: F. Guéritte-Voegelein et al., J. Med. Chem. 34, 992 (1991). Cytotoxic activity and mechanism of action: I. Ringel, S. B. Horwitz, J. Natl. Cancer Inst. 83, 288 (1991). In vivo antitumor activity: M.-C. Bissery et al., Cancer Res. 51, 4845 (1991). HPLC determn: J. C. Vergniol et al., J. Chromatogr. 582, 273 (1992). Clinical pharmacokinetics and toxicology: J.-M. Extra et al., Cancer Res. 53, 1037 (1993). Clinical trials in prostate cancer: I. F. Tannock et al., N. Engl. J. Med. 351, 1502 (2004); D. P. Petrylak et al., ibid. 1513. Symposium on clinical experience: Semin. Oncol. 27, Suppl. 3, 1-29 (2000). Review of mechanism of action and combination therapies: R. S. Herbst, F. R. Khuri, Cancer Treat. Rev. 29, 407-415 (2003); of clinical studies in non-small cell lung cancer: A. M. Davies et al., Expert Opin. Pharmacother. 4, 553-565 (2003).
Properties: mp 232°. [a]D -36° (c = 0.74 in ethanol). uv max: 230, 275, 283 nm (e 14800, 1730, 1670).
Melting point: mp 232°
Optical Rotation: [a]D -36° (c = 0.74 in ethanol)
Absorption maximum: uv max: 230, 275, 283 nm (e 14800, 1730, 1670)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Taxanes.