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CAS No 55-98-1 , 4-methylsulfonyloxybutyl methanesulfonate

  • Name: 4-methylsulfonyloxybutyl methanesulfonate
  • Synonyms: Sulphabutin; Myeloleukon; Mielucin; Myelosan;Myleran;4-methylsulfonyloxybutyl methanesulfonate; Leucosulfan; Busulphan; Misulban; Mylecytan;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 1
  • Melting Point: 114-118 ºC
  • Density: 1.35 g/cm3
  • Safety Statements: R23/24/25;R36/37/38;R45;R46;R63
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-250-2
  • Molecular Weight: 246.30176
  • InchiKey: COVZYZSDYWQREU-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
  • Risk Statements: S28A;S36/37/39;S45;S53
  • Molecular Formula: C6H14O6S2
  • Molecular Structure:CAS No:55-98-1 4-methylsulfonyloxybutyl methanesulfonate
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55-98-1 Busulfan

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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55-98-1 BUSULFAN

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. null,nullChina
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55-98-1 Busulfan

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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55-98-1 Busulfan

  • United States CBSCHEM LIMITED null
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 null,nullUnited States
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55-98-1 Busulfan

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55-98-1 Busulfan

  • United States Tecoland Corporation null
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
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55-98-1 Busulfan

  • Busulfan
  • United States LKT Laboratories, Inc [Manufacturer]
  • Tel: (888)-558-5227
  • Fax:
  • Address: 2233 University Ave. West 55114-1600 St. PaulUNITED STATES 55114-1600 St. Paul,nullUnited States
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55-98-1 BUSULFAN

  • China Shanghai Sunwise Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-21-64063188
  • Fax: +86-21-64062858
  • Address: Shanghai Sunwise Chemical Co., Ltd.
    7G, No 1235 Wuzhong Road
    Shanghai P.R.China null,nullChina
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55-98-1 Busulfan

  • China Taizhou Crene Chempharm Co., Ltd. null
  • Tel: +86-(576)-88813233
  • Fax: +86-(576)-88670057
  • Address: Weiwu Load Economic Developed Zone, Taizhou, Zhejiang 318000, null,nullChina
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55-98-1 Busulfan

  • China Melone Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-41182593631/ +86-41182702105
  • Fax: +86-41182593613
  • Address: Room 2209,No.232, Jinma Road,
    Development Zone,
    Dalian, China 116600 null,nullChina
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References of 4-methylsulfonyloxybutyl methanesulfonate
Title: Busulfan
CAS Registry Number: 55-98-1
CAS Name: 1,4-Butanediol dimethanesulfonate esters
Synonyms: 1,4-bis(methanesulfonoxy)butane; 1,4-di(methanesulfonyloxy)butane; 1,4-di(methylsulfonoxy)butane; methanesulfonic acid tetramethylene ester; tetramethylene bis(methanesulfonate); busulphan
Manufacturers' Codes: CB-2041; GT-41
Trademarks: Busulfex (Orphan Med.); Misulban (Nuovo ISM); Myleran (GSK)
Molecular Formula: C6H14O6S2
Molecular Weight: 246.30
Percent Composition: C 29.26%, H 5.73%, O 38.98%, S 26.04%
Line Formula: CH3SO2O(CH2)4OSO2CH3
Literature References: Alkylating agent with antileukemic activity. Discovery: A. Haddow, G. M. Timmis, Lancet 1, 207 (1953). Prepn: G. M. Timmis, US 2917432 (1959 to Burroughs Wellcome). Chemosterilant effect in boll weevils: J. W. Haynes et al., J. Econ. Entomol. 66, 619 (1973); J. W. Haynes, J. E. Wright, Southwest. Entomol. 7, 56 (1982). Pharmacokinetics: H. Ehrsson et al., Clin. Pharmacol. Ther. 34, 86 (1983). HPLC determn in human plasma: W. D. Henner et al., J. Chromatogr. 416, 426 (1987). Clinical pretreatment with cyclophosphamide, q.v., for bone marrow transplants: G. W. Santos et al., N. Engl. J. Med. 309, 1347 (1983). Comparative clinical trial with mitobronitol, q.v., in chronic myeloid leukemia: R. T. Silver et al., Cancer 60, 1442 (1987). Toxicity data: H. R. Scherf et al., Arzneim.-Forsch. 20, 1467 (1970). Review of pharmacology: C. D. R. Dunn, Exp. Hematol. 2, 101-117 (1974); of toxicology: J. B. Bishop, J. S. Wassom, Mutat. Res. 168, 15-45 (1986). Comprehensive description: M. Tariq, A. A. Al Badr, Anal. Profiles Drug Subs. 16, 53-83 (1987).
Properties: Crystals, mp 114-118°. Soly in acetone at 25°: 2.4 g/100 ml; in alcohol: 0.1 g/100 ml. Practically insol in water, but will dissolve slowly as hydrolysis takes place. LD50 i.v. in rats: 1.8 mg/kg (Scherf).
Melting point: mp 114-118°
Toxicity data: LD50 i.v. in rats: 1.8 mg/kg (Scherf)
CAUTION: This substance is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-39.
Use: Insect sterilant.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Alkyl Sulfonates.