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CAS No 55-98-1 , 4-methylsulfonyloxybutyl methanesulfonate

  • Name: 4-methylsulfonyloxybutyl methanesulfonate
  • Synonyms: Sulphabutin; Myeloleukon; Mielucin; Myelosan;Myleran;4-methylsulfonyloxybutyl methanesulfonate; Leucosulfan; Busulphan; Misulban; Mylecytan;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 1
  • Melting Point: 114-118 ºC
  • Density: 1.35 g/cm3
  • Safety Statements: R23/24/25;R36/37/38;R45;R46;R63
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-250-2
  • Molecular Weight: 246.30176
  • InchiKey: COVZYZSDYWQREU-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
  • Risk Statements: S28A;S36/37/39;S45;S53
  • Molecular Formula: C6H14O6S2
  • Molecular Structure:CAS No:55-98-1 4-methylsulfonyloxybutyl methanesulfonate
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55-98-1 Equipoise

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  • China Hugeraw Health Technology Co.,Ltd. [Manufacturer]
  • Tel: 86-130-06399270
  • Fax: --
  • Address: Area A ,No. 1 Pharmaceutical High Tech Industrial Park,Yao Cheng Avenue,Taizhou ,Jiangsu ,China jiangsu,JiangsuChina
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55-98-1 Busulfan

  • Busulfan Synonyms: Myleran; Busulfex; Busulphan; Tetramethylene bis[methanesulfonate]; 1,4-Dimethanesulfonoxybutane Chemical Name: 1,4-Butanediol, dimethanesulfonate CAS Registry Number: [ 55-98-1 ] Molecular Formula: C6H14O6S2 Molecular Weight: 246....
  • China Wuhan Changland Technology Co.Ltd [Manufacturer]
  • Tel: 86-27-87290719
  • Fax: 86-27-68786490
  • Address: Changland Technology Co.,LTD Wuhan,HubeiChina
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55-98-1 Busulfan

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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55-98-1 Busulfan

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55-98-1 Busulfan

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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55-98-1 Busulfan

  • Busulfan
  • Hong kong Frapp's Pharma (Hongkong) Co.,Ltd [Manufacturer]
  • Tel: +852 8130 0917
  • Fax: +852 8130 0927
  • Address: Room 801,Mongkok Harbour Centre,638 Shanghai Street,Mongkok,Kowloon,Hongkang518001 MongkokHONG KONG Mongkok,Hong kong
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55-98-1 Busulphan

  • Busulphan
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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55-98-1 Busulfan

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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55-98-1 Busulfan

  • Busulfan, 97%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 ,China
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55-98-1 Busulfan

  • Busulfan
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,China
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References of 4-methylsulfonyloxybutyl methanesulfonate
Title: Busulfan
CAS Registry Number: 55-98-1
CAS Name: 1,4-Butanediol dimethanesulfonate esters
Synonyms: 1,4-bis(methanesulfonoxy)butane; 1,4-di(methanesulfonyloxy)butane; 1,4-di(methylsulfonoxy)butane; methanesulfonic acid tetramethylene ester; tetramethylene bis(methanesulfonate); busulphan
Manufacturers' Codes: CB-2041; GT-41
Trademarks: Busulfex (Orphan Med.); Misulban (Nuovo ISM); Myleran (GSK)
Molecular Formula: C6H14O6S2
Molecular Weight: 246.30
Percent Composition: C 29.26%, H 5.73%, O 38.98%, S 26.04%
Line Formula: CH3SO2O(CH2)4OSO2CH3
Literature References: Alkylating agent with antileukemic activity. Discovery: A. Haddow, G. M. Timmis, Lancet 1, 207 (1953). Prepn: G. M. Timmis, US 2917432 (1959 to Burroughs Wellcome). Chemosterilant effect in boll weevils: J. W. Haynes et al., J. Econ. Entomol. 66, 619 (1973); J. W. Haynes, J. E. Wright, Southwest. Entomol. 7, 56 (1982). Pharmacokinetics: H. Ehrsson et al., Clin. Pharmacol. Ther. 34, 86 (1983). HPLC determn in human plasma: W. D. Henner et al., J. Chromatogr. 416, 426 (1987). Clinical pretreatment with cyclophosphamide, q.v., for bone marrow transplants: G. W. Santos et al., N. Engl. J. Med. 309, 1347 (1983). Comparative clinical trial with mitobronitol, q.v., in chronic myeloid leukemia: R. T. Silver et al., Cancer 60, 1442 (1987). Toxicity data: H. R. Scherf et al., Arzneim.-Forsch. 20, 1467 (1970). Review of pharmacology: C. D. R. Dunn, Exp. Hematol. 2, 101-117 (1974); of toxicology: J. B. Bishop, J. S. Wassom, Mutat. Res. 168, 15-45 (1986). Comprehensive description: M. Tariq, A. A. Al Badr, Anal. Profiles Drug Subs. 16, 53-83 (1987).
Properties: Crystals, mp 114-118°. Soly in acetone at 25°: 2.4 g/100 ml; in alcohol: 0.1 g/100 ml. Practically insol in water, but will dissolve slowly as hydrolysis takes place. LD50 i.v. in rats: 1.8 mg/kg (Scherf).
Melting point: mp 114-118°
Toxicity data: LD50 i.v. in rats: 1.8 mg/kg (Scherf)
CAUTION: This substance is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-39.
Use: Insect sterilant.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Alkyl Sulfonates.