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CAS No 77-86-1 , 2-amino-2-(hydroxymethyl)propane-1,3-diol

  • Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
  • Synonyms: Tris buffer; Tris(Hydroxymethyl)aminomethane; Trisamine; Tromethane;2-amino-2-(hydroxymethyl)propane-1,3-diol; Trizma;Trometamol; Tris; Tham; 77-86-1;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 167-172 ºC
  • Boiling Point: 219-220 ºC (10 MMHG)
  • Density: 1,353 g/cm3
  • Refractive index: 1.531
  • Water Solubility: 550 G/L (25 ºC)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • HS Code: 29221980
  • EINECS: 201-064-4
  • Molecular Weight: 121.13504
  • InchiKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
  • Risk Statements: S26;S37/39
  • Molecular Formula: C4H11NO3
  • Molecular Structure:CAS No:77-86-1 2-amino-2-(hydroxymethyl)propane-1,3-diol
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77-86-1 Tris(hydroxymethyl)aminoethane

  • China HuaiBei SanHe Developing Co., Ltd. [Manufacturers]
  • Tel: 86-561-3191113
  • Fax: +86-561-3192253
  • Address: Room 201,Building ZY-1,GuCheng Road,Huaibei,Anhui,China null,anhuiChina
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77-86-1 TRIZMA BASE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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77-86-1 Tris(Hydroxymethyl)Aminomethane

  • China Shanghai Sunwise Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-21-64063188
  • Fax: +86-21-64062858
  • Address: Shanghai Sunwise Chemical Co., Ltd.
    7G, No 1235 Wuzhong Road
    Shanghai P.R.China null,nullChina
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77-86-1 Tris(hydroxymethyl)aminoethane

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 null,nullChina
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77-86-1 TRIS BUFFER GRADE

  • Germany AppliChem GmbH [Manufacturer]
  • Tel: +49 6151 93 57 0
  • Fax: +49 6151 93 57 11
  • Address: AppliChem GmbH
    Ottoweg 4
    64291 Darmstadt
    Germany null,nullGermany
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77-86-1 Tri(hydroxymethyl)aminomethane

  • China Shanghai Experiment Reagent Co.,LTD. [Manufacturers]
  • Tel: 0086-21-56558317 56553837
  • Fax: +86-21-56553837
  • Address: 10-603, No.555 Luding Road (No.1000 North Zhongshan Road),Shanghai Shanghai,ShanghaiChina
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77-86-1 Tris(hydroxymethyl)aminoethane

  • India Nile Chemicals [Manufacturers]
  • Tel: +91-(22)-66313162, 23454828
  • Fax: +91-(22)-23454828
  • Address: 202, Matruchhaya, 378/80 Narshi Natha Street, Mumbai, Maharashtra 400 009, Mumbai,MumbaiIndia
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77-86-1 EC-406-1K TRIS BUFFER

  • United Kingdom AGTC Bioproducts Ltd [Manufacturer]
  • Tel: +44(0)1482646020
  • Fax: +44(0)1482646013
  • Address: AGTC Bioproducts Ltd
    Unit 4 Fleet Business Park, Hessle,
    ERY, HU13 9LX
    United Kingdom null,nullUnited Kingdom
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77-86-1 Tris(hydroxymethyl)aminoethane

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77-86-1 TRIS (HYDROXYMETHYL) AMINO METHANE USP

  • United States Aceto Corp. [Manufacturer]
  • Tel: 516-627-6000
  • Fax: 516-627-6093
  • Address: One Hollow Lane
    Lake Success, NY 11042-1215 null,nullUnited States
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References of 2-amino-2-(hydroxymethyl)propane-1,3-diol
Title: Tromethamine
CAS Registry Number: 77-86-1
CAS Name: 2-Amino-2-hydroxymethyl-1,3-propanediol
Synonyms: trimethylol aminomethane; tris(hydroxymethyl)aminomethane; trisamine; tris buffer; trometamol; tromethane; TRIS
Trademarks: THAM (Fisher Sci.); Trizma (Sigma-Aldrich)
Molecular Formula: C4H11NO3
Molecular Weight: 121.14
Percent Composition: C 39.66%, H 9.15%, N 11.56%, O 39.62%
Literature References: May be prepd by reduction or catalytic hydrogenation of the corresp nitro compd. Prepn of similar compds: Hass, Vanderbilt, US 2174242 (1940); Johnson, Degering, J. Org. Chem. 8, 7 (1943); Boileau, Mem. Poudres 35, Annexe 7-76 (1953). Prepn by electrolytic reduction: McMillan, US 2485982 (1949 to Comm. Solvents Corp.). Titrimetric standard: Whitehead, J. Chem. Educ. 36, 297 (1959). Monograph: Ann. N.Y. Acad. Sci. 92, Art. 2, pp 333-812 (June 17, 1961). Crystal structure: R. Rudman et al., Science 200, 531 (1978). GC determn in plasma: H. Hulshoff, H. B. Kostenbauder, J. Chromatogr. 145, 155 (1978). Pharmacokinetics in rabbits: H. Brasch, H. Iven, Arch. Int. Pharmacodyn. 254, 4 (1981). Use as a biological buffer: R. A. Durst, B. R. Staples, Clin. Chem. 18 206 (1972); S. P. Fling, D. S. Gregerson, Anal. Biochem. 155, 83 (1986); T. Higa, D. M. Desiderio, ibid. 173, 463 (1988). Interaction with hydroxyl radicals: M. Hicks, J. M. Gebicki, FEBS Lett. 199, 92 (1986). Review of clinical experience in treatment of acidemia: G. G. Nahas et al., Drugs 55, 191-224 (1998).
Properties: Crystalline mass, mp 171-172°. bp10 219-220°. Weak, monoacidic base: pKb (25°): 5.91. pKa (20°): 8.3. pKa (37°): 7.82. pH of 0.1 molar aq soln 10.4. Aq solns do not absorb CO2 from the air. Soly at 25° (mg/ml) in water: 550; ethylene glycol: 79.1; methanol: 26; anhydr ethanol: 14.6; 95% ethanol: 22.0; DMF: 14; acetone: 2.0; ethyl acetate: 0.5; olive oil: 0.4; cyclohexane: 0.1; chloroform: 0.05; carbon tetrachloride: <0.05.
Melting point: mp 171-172°
Boiling point: bp10 219-220°
pKa: pKb (25°): 5.91; pKa (20°): 8.3; pKa (37°): 7.82
Use: In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
Therap-Cat: Alkalinizing agent.
Keywords: Alkalinizing Agent.