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CAS No 77-86-1 , 2-amino-2-(hydroxymethyl)propane-1,3-diol

  • Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
  • Synonyms: Tris buffer; Tris(Hydroxymethyl)aminomethane; Trisamine; Tromethane;2-amino-2-(hydroxymethyl)propane-1,3-diol; Trizma;Trometamol; Tris; Tham; 77-86-1;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 167-172 ºC
  • Boiling Point: 219-220 ºC (10 MMHG)
  • Density: 1,353 g/cm3
  • Refractive index: 1.531
  • Water Solubility: 550 G/L (25 ºC)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • HS Code: 29221980
  • EINECS: 201-064-4
  • Molecular Weight: 121.13504
  • InchiKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
  • Risk Statements: S26;S37/39
  • Molecular Formula: C4H11NO3
  • Molecular Structure:CAS No:77-86-1 2-amino-2-(hydroxymethyl)propane-1,3-diol
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77-86-1 Tris(hydroxymethyl)aminoethane

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77-86-1 TROMETHAMINE

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77-86-1 Tris(hydroxymethyl)aminoethane

  • Czech Republic LACH-NER, s.r.o. [Manufacturers]
  • Tel: +420 315 618 369 +420 541 127 236
  • Fax: +420 315 684 008 +420 541 127 633
  • Address: Karásek 1 621 33 Brno Czech Republic Brno,BrnoCzech Republic
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77-86-1 Tromethamine

  • China 3C Chemical Co., Ltd. null
  • Fax: +86-25-83204627
  • Address: 5F Shenhe Mansion, 81 Yunnan Road (North), Nanjing,P.R.China null,nullChina
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77-86-1 Tris(hydroxymethyl)aminoethane

  • Canada Onbio Inc. [Manufacturers]
  • Tel: +1-(905)707-1241 ++1.905.780.1700
  • Fax: +1-(905)707-0041
  • Address: 26 Benson Avenue, Suite 101, Richmond Hill, Ontario, Canada L4C 4E6 Richmond Hill,OntariCanada
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77-86-1 Tris(hydroxymethyl)aminoethane

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77-86-1 Tris(Hydroxymethyl)Aminomethane

  • Product name: Tris(Hydroxymethyl)Aminomethane CAS NO.:77-86-1 Appareance: White crystalline powder Purity:99%
  • China Zhangjiagang Xikai Chemical Co.,Ltd [Manufacturers]
  • Tel: +86-0512-55701600 86-512-55329108
  • Fax: 86-512-58538687
  • Address: No.1 north guotai road,zhangjiagang economical zone Zhangjiagang,JiangsuChina
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77-86-1 TRIS(HYDROXYMETHYL)AMINOMETHANE

  • China Robiot Co.,Ltd. [Manufacturer]
  • Tel: +86-25-84391875
  • Fax: :+86-25-84391596
  • Address: Robiot Co.,Ltd.
    NO.50 Zhongling St.
    Nanjing City
    China null,nullChina
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77-86-1 Tris(hydroxymethyl)aminoethane

  • United States Mallinckrodt Baker, Inc. null
  • Tel: +1 (908) 859-2151 (outside U.S.)
  • Fax: +1 (908) 859-6905
  • Address: 222 Red School Lane Phillipsburg, NJ 08865 null,nullUnited States
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77-86-1 Tris(Hydroxymethyl)Aminomethane

  • China Sino World Chemical Canada Inc. [Manufacturers]
  • Tel: +86-(10)-6493-1655
  • Fax: +86-(10)-6493-1652
  • Address: A-3 Jianguomenwai Street, Beijing 100020, Beijing,BeijingChina
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References of 2-amino-2-(hydroxymethyl)propane-1,3-diol
Title: Tromethamine
CAS Registry Number: 77-86-1
CAS Name: 2-Amino-2-hydroxymethyl-1,3-propanediol
Synonyms: trimethylol aminomethane; tris(hydroxymethyl)aminomethane; trisamine; tris buffer; trometamol; tromethane; TRIS
Trademarks: THAM (Fisher Sci.); Trizma (Sigma-Aldrich)
Molecular Formula: C4H11NO3
Molecular Weight: 121.14
Percent Composition: C 39.66%, H 9.15%, N 11.56%, O 39.62%
Literature References: May be prepd by reduction or catalytic hydrogenation of the corresp nitro compd. Prepn of similar compds: Hass, Vanderbilt, US 2174242 (1940); Johnson, Degering, J. Org. Chem. 8, 7 (1943); Boileau, Mem. Poudres 35, Annexe 7-76 (1953). Prepn by electrolytic reduction: McMillan, US 2485982 (1949 to Comm. Solvents Corp.). Titrimetric standard: Whitehead, J. Chem. Educ. 36, 297 (1959). Monograph: Ann. N.Y. Acad. Sci. 92, Art. 2, pp 333-812 (June 17, 1961). Crystal structure: R. Rudman et al., Science 200, 531 (1978). GC determn in plasma: H. Hulshoff, H. B. Kostenbauder, J. Chromatogr. 145, 155 (1978). Pharmacokinetics in rabbits: H. Brasch, H. Iven, Arch. Int. Pharmacodyn. 254, 4 (1981). Use as a biological buffer: R. A. Durst, B. R. Staples, Clin. Chem. 18 206 (1972); S. P. Fling, D. S. Gregerson, Anal. Biochem. 155, 83 (1986); T. Higa, D. M. Desiderio, ibid. 173, 463 (1988). Interaction with hydroxyl radicals: M. Hicks, J. M. Gebicki, FEBS Lett. 199, 92 (1986). Review of clinical experience in treatment of acidemia: G. G. Nahas et al., Drugs 55, 191-224 (1998).
Properties: Crystalline mass, mp 171-172°. bp10 219-220°. Weak, monoacidic base: pKb (25°): 5.91. pKa (20°): 8.3. pKa (37°): 7.82. pH of 0.1 molar aq soln 10.4. Aq solns do not absorb CO2 from the air. Soly at 25° (mg/ml) in water: 550; ethylene glycol: 79.1; methanol: 26; anhydr ethanol: 14.6; 95% ethanol: 22.0; DMF: 14; acetone: 2.0; ethyl acetate: 0.5; olive oil: 0.4; cyclohexane: 0.1; chloroform: 0.05; carbon tetrachloride: <0.05.
Melting point: mp 171-172°
Boiling point: bp10 219-220°
pKa: pKb (25°): 5.91; pKa (20°): 8.3; pKa (37°): 7.82
Use: In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
Therap-Cat: Alkalinizing agent.
Keywords: Alkalinizing Agent.